Dynamical mechanism of parkinsonian beta oscillation in a heterogenous subthalamopallidal network

Dysfunction of basal ganglia is associated with the pathogenesis Parkinson's disease including alteration firing rate and excessive beta-band (13-30 Hz) synchronization activity. Neuronal heterogeneity enriches dynamics external globus pallidus (GPe), especially showing significant differences in alterations under pathological state. The precise mechanism underlying these neural signatures remains elusive. To address this, we propose a subthalamopallidal network containing two classes GPe neurons, calcium-binding protein parvalbumin (PV) Lim homeobox (Lhx6) GPe. Our results show that Lhx6 tends to rein synchronous behavior abnormal activity PV Under condition, synaptic coupling heterogenous pallidal manifests itself as direct increase inhibitory input or an indirect elevation rate. These essentially enhance inhibition GPe, which bursting. subthalamic nucleus (STN) instrumental stabilizing spiking sequence inhibiting oscillations both control conditions. In dopamine-depleted state, GPe-PV pathway notably impacts enhancement beta rhythmic STN-GPe circuit. Besides, affect propagation rhythms networks, respectively. study highlights pivotal role played by producing amplifying oscillatory behavior. suggest STN prevents rhythm providing novel insight into affects